PHARMA LAB · PL-03

Liquid Handling & Sample Preparation

Reliable analysis starts before the instrument.

Start with the liquid, sample matrix and volume you need to handle. Explore pipetting, dispensing, dilution, extraction and weighing, together with the equipment that prepares a sample for analysis.

Pipettes, centrifuge, analytical balance and sample tubes for laboratory sample preparation.

Choose the operation you need to control.

Explore equipment, practical technique and traceability, from initial weighing to a sample ready for measurement.

01

Pipettes & pipetting technique

Pipette selection, forward and reverse pipetting, multichannel and electronic models, and tips. Connect use, cleaning, maintenance and fleet management with the properties of the liquid.

02

Dispensing & automated handling

Bottle-top dispensers, burettes and automated liquid handling systems. Define volumes, compatibility and operating requirements before comparing equipment configurations.

03

Preparation, dilution & filtration

Step-by-step traceability, serial dilutions, extraction, syringe filters, concentration and evaporation. Assess recovery, analyte losses and potential sources of contamination.

04

Centrifugation & mixing

Centrifuges, rotors and the difference between RPM and RCF; vortex mixers, orbital shakers, homogenisers and sonication. Explore selection, qualification and checks appropriate to the operation.

05

Weighing & balance selection

Capacity, readability, environment, weighing technique, static electricity and sample transfer. Distinguish balance selection and use from its metrological assessment.

Operating technique and calibration: connected, not duplicated.

This hub covers selection, use and control of sample preparation. Pipette and balance calibration methods belong to Calibration & Laboratory Metrology; electronic sample and record management remains in Digital Lab.

EXPERT SUPPORT

Working on a laboratory project?

Describe the instrument, intended use and support you need. GuideGxP will review the request and, where appropriate, may connect you with a suitable specialist.

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